› best-weed-killers-4173508The 12 Best Weed Killers of 2022 | by The Spruce Aug 31, 2022 · Some herbicides are non-selective, which means they kill all plants they encounter. (Round-Up, a glyphosate-based herbicide, is a widely available type of non-selective weed killer.) Most gardeners prefer selective weed killers, which affect only the growth of targeted species. They are used mostly for broadleaf weed control.